Active RiboNucleic Acid selection and analysis KIT
An Italian startup, specialised in RNA (RiboNucleic Acid) analysis, delivers smart solutions for better gene expression studies. The company offers technologies to assess translational control of gene expression and translatome associated biomarkers.
The uniqueness of the core technology resides in the selective isolation of actively translated mRNAs. Kit for better ribosome profiling are available. The company is looking for commercial agreements, licencing and research collaborations.
Инновационные аспекты и преимущества
1) fast protocol (10x). No more 24 hours of polysome profile required as for other existing products;
B) it works reliably with low amounts of input material. Less than 10^5 cells are required for isolation of active ribosome protected fragments;
C) it can be easily and rapidly applied both in vitro and in vivo, thereby generating a global snapshot of active ribosome footprints at single nucleotide resolution. No other tolls can generate a snapshot of protein expression with such degree of
resolution and accuracy;
4) thanks to a novel method based on an original puromycin-containing molecule (patented) capable of isolating active ribosomes, the company can offer the only technology on the market able to quantify active ribosomes.
Main advantages compared to existing kits:
1) fastness: 120 min sample prep;
2) no more polysome profile (2 days);
3) more accurate gene expression analysis.
Коды рыночных применений
04004 Other Genetic Engineering / 04005 Biochemistry / Biophysics / 04015 Gene Expression, Proteome Research
The Italian company, a start up born in 2014 and managed by a young team of PhD's ("Doctors on Philosophy") with academic experience in biomolecular science and material chemistry, is located in a scientific science park and specialised in RNA (RiboNucleic Acid) analysis and delivering of smart solutions for better gene expression studies. It offers a technology for better ribosome profiling studies, by means of an antibody-free and tag-free pull-down approach to capture only active ribosomes.
Typical applications are:
- measurements of gene expression at the level of actual protein synthesis
- assay on drugs acting at the translatome level
- discovery of new prognostic biomarkers in cancer and neurodegenerative diseases
- speed up the validation of existing biomarkers in cancer
Features of the technology:
1) 120 min prep. – and no more polysome profile (2 days)
3) extraction of ribosome protected RNA fragments only from active ribosomes
4) antibody free
5) basic kit composition: magnetic beads, active polymer, buffer 1, buffer 2, buffer 3
6) custom kit availability
The company is looking for commercial agreement, research cooperation agreements and license agreement.
In case of commercial agreement the partner should be a biological laboratory that will be provided with kits for biological testing.
In case of research cooperation, the partner should be a biological laboratory using the kits for testing biological applications.
In case of license agreement, the partner should be an industry working in biological pharmaceutical sector and it should use the licence to produce complementary technologies
Права интеллектуальной собственности
Patent(s) applied for but not yet granted
Albania / Argentina / Armenia / Austria / Belarus / Belgium / Bosnia and Herzegovina / Brazil / Bulgaria / Canada / Chile / China / Croatia / Cyprus / Czech Republic / Denmark / Egypt / Estonia / Finland / France / Georgia / Germany / Greece / Hungary / Iceland / India / Ireland / Israel / Italy / Japan / Jordan / Latvia / Lithuania / Luxembourg / Macedonia, The former Yugoslav Republic of / Malta / Mexico / Moldova / Montenegro / Netherlands / New Zealand / Norway / Paraguay / Peru / Poland / Portugal / Romania / Russian Federation / Serbia / Singapore / Slovakia / Slovenia / South Korea / Spain / Sweden / Switzerland / Taiwan / Tunisia / Turkey / Ukraine / United Kingdom / USA
Текущая стадия развития
The startup just started the Early Access Programme (EAP) for the core technology. The EAP allows innovative researchers to get first access to the novel technology. Fourteen (14) labs involved worldwide.
Технологические ключевые слова
06001012 Medical Research / 06001015 Pharmaceutical Products / Drugs / 06002002 Cellular and Molecular Biology / 06003002 Gene Expression, Proteom Research / 06006012 Bioprocesses
Тип искомого партнера
In case of commercial agreement the company is looking for biological laboratories that are interested in using the company's kits for biological testing.
The company will provide kits by courier to the laboratory and assist this latter giving hints and instructions for correct use.
In case of research cooperation, the partner should be a biological laboratory and it would use the kits for testing biological applications.
In case of license agreement, the partner should be an industry working in biological pharmaceutical sector. The company would license its know-how (in terms of patents and knowledge) to the partner, that would produce technologies complementary to those already produced by the company.
Тип требующегося сотрудничества
License Agreement / Commercial agreement with technical assistance / Research cooperation agreement
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